Answers.com tells us the average male American Bison weighs 1,199–1,999.5 lbs. The average female weighs 701–1,201 lbs and they travel in herds.
The curb weight of a 2007 Ford Fusion is about 3,100 lbs. When a bison herd meets a 2007 Ford Fusion who do you think wins? Surprisingly it is kind of a standoff, although the Ford Fusion was totalled, according to this autoblog story. Fortunately, the driver walked away. Can't say the same thing about some of the bison.